Department of Bioengineering, Imperial College London
We work at the interface between engineering and neuroscience. Our aim is to understand how sensory information is processed by neural circuits in the mammalian cerebral and cerebellar cortices, including how it is used in elementary cognitive operations. Understanding how the “cortical circuit” processes information helps us to understand how it it dysfunctions in neurodegenerative disorders such as Alzheimer’s Disease, and also aids in the design of novel computational devices. Our work involves both neuroscience experiments and theoretical/computational work. We use a number of technologies to probe cortical circuit function - two photon calcium imaging, optogenetic disruption of genetically targeted cells, and electrophysiology. We also develop novel algorithms, based particularly on information theory, for analysing the resulting high-dimensional datasets.