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Simon Schultz grew up in North East Victoria, Australia, attending school in Wangaratta. He graduated with a BSc/BEng from Monash University, in Physics and Electrical Engineering, and from Sydney University with a Masters in Electrical Engineering, before reading for a DPhil in Neuroscience at the University of Oxford. He has held research fellowship positions at New York University and University College London. He is currently Reader in Neurotechnology, and Royal Society Industry Fellow, at Imperial College London, where he directs the Neural Coding Laboratory.

He has been a leader in the development of quantitative, information-theoretic algorithms for the analysis of large neurophysiological datasets, with key highly cited papers on the roles of spike timing and correlations in sensory coding. Research in his group focuses on studying sensory and cognitive neural codes, and how they relate to cortical circuit structure. A current focus is on the use of optical techniques to probe neural circuit function.

He served on the National Committee of the British Neuroscience Association from 2009-13 as Membership Secretary, and is on the Editorial board of the Journal of Computational Neuroscience.